Brock's Blog

Formerly Virtually Shocking

Second CSM Demo - Activation Mapping and More

2009-09-04 06:06:24
Today the latest CSM demo video went live on the CardioSolv site. It showcases the use of our mapping interface, which makes it easy to create useful maps of activity in simulation models. It's currently non-trivial to show movies in papers, so instead we do time-lapse type things called activation maps. These show the activation times as a series of lines ('isochrones' or 'isochronal lines', meaning that all of the points on the line are activated at the same time) or bands of color representing the same thing. We can extend this to also show repolarization times, or non-sequential data such as action potential duration maps and dominant frequency maps. Here's a sample activation map of a wave moving across a sheet from right to left: [caption id="attachment_1409" align="aligncenter" width="320" caption="Activation Map Right to Left"]Activation Map Right to Left[/caption] And here's one of a spiral (this with 20ms isochrones): [caption id="attachment_1410" align="aligncenter" width="320" caption="Activation Map of a Spiral Wave"]Activation Map of a Spiral Wave[/caption] To give you an idea of the correspondence between an activation map and a movie of the simulation, here's a movie of that spiral: Spiral Wave There's a lot more to this -- for instance, deciding when a cell has activated or repolarized, and back-end processing. We use a program I wrote that does the analysis in parallel, making it rather quick to analyze even huge datasets, provided you have the computing power. If you have any questions about the process I'd be happy to answer them here or on the CardioSolv post.

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